Biomaterials have had a major impact on the practice of contemporary medicine and patient care. Growing into a major interdisciplinary effort involving chemists, biologists, engineers, and physicians, biomaterials development has enabled the creation of high-quality devices, implants, and drug carriers with greater biocompatibility and biofunctionality. The fast-paced research and increasing interest in finding new and improved biocompatible or biodegradable polymers has provided a wealth of new information, transforming this edition of Polymeric Biomaterials into a two-volume set. Completely revised and expanded, this state-of-the-art reference presents recent developments in polymeric biomaterials: from their chemical, physical, and structural properties to current applications in the medical and pharmaceutical fields. The book is organized into two volumes containing 53 authoritative chapters written by experts from around the world.
The first volume, Polymeric Biomaterials: Structure and Function, contains information about the structure and properties of synthetic polymers including polyesters, polyphosphazenes, and elastomers and natural polymers such as mucoadhesives, chitin, lignin, and carbohydrate derivatives. It also describes their blends or composites-for example, metal-polymer composites and biodegradable polymeric/ceramic composites-as well as drug carriers and delivery systems, gene and nucleic acids delivery, and polymer synthesis and processing techniques. The second volume, Polymeric Biomaterials: Medicinal and Pharmaceutical Applications, addresses processing of polymeric biomaterials into specific forms that ensure biocompatibility and biodegradability for various uses in the medical and pharmaceutical arenas. The chapters address numerous medical issues including pulmonary disease, cancer, heart disease, tissue damage, and bone disease. The applications covered include a variety of drug delivery systems, medical devices, anticancer therapies, biological uses for hydrogels, nanotechnology, bioartificial organs, and tissue engineering.
This third edition set presents new and substantially revised topics, providing a comprehensive reference of the latest developments and the most up-to-date applications of biomaterials in medicine.
Volume 1: Synthesis and Fabrication of Polyesters as Biomaterials Philippe Lecomte and Christine Jerome Hydrogels Formed by Cross-Linked Poly(Vinyl Alcohol) Gaio Paradossi Development and Evaluation of Poly(Vinyl Alcohol) Hydrogels as a Component of Hybrid Artificial Tissues for Orthopedics Surgery Application Masanori Kobayashi Polyphosphazenes as Biomaterials Meng Deng, Cato T. Laurencin, Harry R. Allcock, and Sangamesh G. Kumbar Biodegradable Polymers as Drug Carrier Systems Abraham J. Domb and Wahid Khan Bioresorbable Hybrid Membranes for Bone Regeneration Akiko Obata and Toshihiro Kasuga Mucoadhesive Polymers: Basics, Strategies, and Future Trends Andreas Bernkop-Schnurch Biodegradable Polymeric/Ceramic Composite Scaffolds to Regenerate Bone Tissue Catherine Gkioni, Sander Leeuwenburgh, and John Jansen Amphiphilic Systems as Biomaterials Based on Chitin, Chitosan, and Their Derivatives Jacques Desbrieres Biomaterials of Natural Origin in Regenerative Medicine Vijay Kumar Nandagiri, Valeria Chiono, Piergiorgio Gentile, Franco Maria Montevecchi, and Gianluca Ciardelli Natural Polymers as Components of Blends for Biomedical Applications Alina Sionkowska Metal-Polymer Composite Biomaterials Takao Hanawa Evolution of Current and Future Concepts of Biocompatibility Testing Menno L.W. Knetsch Biocompatibility of Elastomers Dominique Chauvel-Lebret, Pascal Auroy, and Martine Bonnaure-Mallet Preparation and Applications of Modulated Surface Energy Biomaterials Blanca Vazquez, Luis M. Rodriguez-Lorenzo, Gema Rodriguez-Crespo, Juan Parra, Mar Fernandez, and Julio San Roman Electrospinning for Regenerative Medicine Toby D. Brown, Cedryck Vaquette, Dietmar W. Hutmacher, and Paul D. Dalton Polymeric Nanoparticles for Targeted Delivery of Bioactive Agents and Drugs Cesare Errico, Alberto Dessy, Anna Maria Piras, and Federica Chiellini Polymeric Materials Obtained through Biocatalysis Florin Dan Irimie, Csaba Paizs, and Monica Ioana Tosa Polymer-Based Colloidal Aggregates as a New Class of Drug Delivery Systems Cesare Cametti Photoresponsive Polymers for Control of Cell Bioassay Systems Kimio Sumaru, Shinji Sugiura, Toshiyuki Takagi, and Toshiyuki Kanamori Lignin in Biological Systems Valentin I. Popa Carbohydrate-Derived Self-Crosslinkable In Situ Gelable Hydrogels for Modulation of Wound Healing Lihui Weng, Christine Falabella, and Weiliam Chen Dental and Maxillofacial Surgery Applications of Polymers E.C. Combe Biomaterials as Platforms for Topical Administration of Therapeutic Agents in Cutaneous Wound Healing Rhiannon Braund and Natalie J. Medlicott Polymers for Artificial Joints Masayuki Kyomoto, Toru Moro, and Kazuhiko Ishihara Volume 2: Antithrombin-Heparin Complexes Leslie R. Berry and Anthony K.C. Chan Glucose-Sensitive Hydrogels Seong Hoon Jeong, Kyung T. Oh, and Kinam Park Advances in Polymeric and Lipid-Core Micelles as Drug Delivery Systems Tiziana Musacchio and Vladimir P. Torchilin Modular Biomimetic Drug Delivery Systems Carmen Alvarez-Lorenzo, Fernando Yanez- Gomez, and Angel Concheiro Polymeric Nanoparticles for Drug Delivery Karine Andrieux, Julien Nicolas, Laurence Moine, and Gillian Barratt Drug Carrier Systems for Anticancer Agents Hiroyuki Koide, Tomohiro Asai, Kosuke Shimizu, and Naoto Oku Application of Polymer Drugs to Medical Devices and Preparative Medicine M.R. Aguilar, L. Garcia-Fernandez, M.L. Lopez-Donaire, F. Parra, L. Rojo, G. Rodriguez, M.M. Fernandez, and J. San Roman Polymer Implants for Intratumoral Drug Delivery and Cancer Therapy Brent D. Weinberg and Jinming Gao Biological Stimulus-Responsive Hydrogels A.K. Bajpai, Sanjana Kankane, Raje Chouhan, and Shilpi Goswami Polymeric Materials for Surface Modification of Living Cells Yuji Teramura, Hao Chen, Naohiro Takemoto, Kengo Sakurai, and Hiroo Iwata Biomedical Applications of Shape Memory Polymers and Their Nanocomposites I. Sedat Gunes and Sadhan C. Jana Bioadhesive Drug Delivery Systems Ryan F. Donnelly and A. David Woolfson Nanomedicines Coming of Age Radoslav Savic, Jinzi Zheng, Christine Allen, and Dusica Maysinger Polymers for Myocardial Tissue Engineering J.A. Roether, H. Jawad, R. Rai, N.N. Ali, S.E. Hardling, and A.R. Boccaccini Acellular Tubular Grafts Constructed from Natural Materials in Vascular Tissue Engineering M.J.W. Koens, A.G. Krasznai, J.A. van der Vliet, T. Hendriks, R.G. Wismans, K.A. Faraj, W.F. Daamen, and T.H. van Kuppevelt pH-Responsive Polymers for Delivery of Nucleic Acid Therapeutics Yu Nie and Ernst Wagner Adhesive Biomaterials for Tissue Repair and Reconstruction Sujata K. Bhatia Polymeric Interactions with Drugs and Excipients James C. DiNunzio and James W. McGinity Manufacturing Multifunctional Scaffolds for Tissue Engineering Vincenzo Guarino, Antonio Gloria, Roberto De Santis, and Luigi Ambrosio Virus-Based Nanoparticles as Drug Delivery Systems Eva Roblegg and Andreas Zimmer Polymeric Biomaterials in Pulmonary Drug Delivery Nicole A. Beinborn and Robert O. Williams III Polymeric Gene Delivery Carriers for Pulmonary Diseases Xiang Gao, Regis R. Vollmer, and Song Li Biomedical Application of Membranes in Bioartificial Organs and Tissue Engineering Thomas Groth, Xiao-Jun Huang, and Zhi-Kang Xu Controlled Release Systems for Bone Regeneration Hossein Hosseinkhani Controlled Release Systems Targeting Angiogenesis Stephanie Deshayes, Karine Gionnet, Victor Maurizot, and Gerard Deleris Bioceramics for Development of Bioartificial Liver Tomokazu Matsuura and Mamoru Aizawa Materials Biofunctionalization for Tissue Regeneration Laura Cipolla, Laura Russo, Nasrin Shaikh, and Francesco Nicotra Polymers-Based Devices for Dermal and Transdermal Delivery Donatella Paolino, Margherita Vono, and Felisa Cilurzo